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1994-10-25
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Document 3023
DOCN M94A3023
TI AIDS-associated Kaposi sarcoma and incidence of gastrointestinal
involvement--how efficient is endoscopy.
DT 9412
AU Liess H; Zoller WG; Bogner J; Powitz F; Zietz C; Goebel FD; Medizinische
Poliklinik, University of Munich, Germany.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):171 (abstract no. PB0112). Unique
Identifier : AIDSLINE ICA10/94369552
AB OBJECTIVE: Gastrointestinal involvement of AIDS-associated Kaposi
Sarcoma (KS) may be of major prognostic as well as therapeutic
relevance. Therefore the incidence of gastrointestinal involvement was
retrospectively analysed using data from autopsies performed in an
unselected group of patients (pts.) with AIDS. METHODS/PATIENTS: 306
(286 male, 20 female) pts. who died from AIDS were investigated. They
had all been treated at the Medizinische Poliklinik (Period of
registration: Jan. 1st 1984-May 1st 1993). 257 pts. belonged to the high
risk group of homo/bisexuals. 23 pts. had used i.v. drugs, 26 pts. had
no apparent risk for HIV-infection. All findings assessed intra vitam as
well as autopsy findings were analysed. RESULTS: Investigation of the
gastrointestinal tract (GIT) was performed in 228 (74,5%) pts.. This
revealed pathological findings (intra vitam or post-mortem) in 145
(63,6%) of these cases. 50 (21,9%) of these were KS. An autopsy was
performed in a total of 76 (24,8%) pts.. In 50 (46,3%) of 108 pts.
diagnosed with cutaneous KS endoscopy and autopsy together could show
GIT involvement. In 39 pts. Kaposi lesions were found intra vitam. In 11
pts. visceral-abdominal involvement was found at time of autopsy. Of
these 9 pts. had not had an endoscopy. 2 pts. showed an involvement of
the spleen or liver exclusively. All pts. with possibly visible lesions
were correctly diagnosed if endoscopy was performed. CONCLUSIONS:
Endoscopy detected GIT involvement of KS in almost all patients. Due to
high incidence and the potential therapeutic consequences (local versus
systemic) we conclude that endoscopy should be performed in all pts.
diagnosed with cutaneous AIDS-associated KS.
DE Acquired Immunodeficiency Syndrome/*DIAGNOSIS/PATHOLOGY/ TRANSMISSION
*Endoscopy, Gastrointestinal Female Gastrointestinal
Neoplasms/*DIAGNOSIS/PATHOLOGY Gastrointestinal System/PATHOLOGY Human
Male Neoplasms, Second Primary/DIAGNOSIS/PATHOLOGY Retrospective
Studies Risk Factors Sarcoma, Kaposi's/*DIAGNOSIS/PATHOLOGY Skin
Neoplasms/DIAGNOSIS/PATHOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).